2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-152012S
    Tetradecanoylcarnitine-d3 hydrochloride 1297271-54-5 98%
    Tetradecanoylcarnitine-d3 (hydrochloride) is deuterium labeled Tetradecanoylcarnitine. Tetradecanoylcarnitine is a human carnitine involved in β-oxidation of long-chain fatty acids.
    Tetradecanoylcarnitine-d3 hydrochloride
  • HY-152015S
    Acetyl-L-carnitine-d6 hydrochloride 2692624-01-2 98%
    Acetyl-L-carnitine-d6 (hydrochloride) is a deuterated Acetyl-L-carnitine. Acetyl-L-carnitine is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier.
    Acetyl-L-carnitine-d6 hydrochloride
  • HY-152016S
    DL-Carnitine-d9 hydrochloride 2692624-07-8 98%
    DL-Carnitine-d9 (hydrochloride) is the deuterium labeled (±)-Carnitine. (±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
    DL-Carnitine-d9 hydrochloride
  • HY-15206S2
    Glibenclamide-13C6 98%
    Glibenclamide-13C6 (Glyburide-13C6) is 13C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide can induce autophagy.
    Glibenclamide-13C6
  • HY-15258S1
    Lesinurad-d4 1850305-60-0 98%
    Lesinurad-d4 (RDEA594-d4) is deuterium labeled Lesinurad. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
    Lesinurad-d4
  • HY-153871A
    C24:1 Mono-sulfo Galactosyl (α) ceramide (d18:1/24:1) ammonium 2260670-38-8 98%
    C24:1 Mono-sulfo Galactosyl (α) ceramide (d18:1/24:1) (ammonium) is a glycosphingolipid.
    C24:1 Mono-sulfo Galactosyl (α) ceramide (d18:1/24:1) ammonium
  • HY-15398AR
    5,6-trans-Vitamin D3 (Standard) 22350-41-0 98%
    5,6-trans-Vitamin D3 (Standard) is the analytical standard of 5,6-trans-Vitamin D3. This product is intended for research and analytical applications. 5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.
    5,6-trans-Vitamin D3 (Standard)
  • HY-15408AR
    Trelagliptin succinate (Standard) 1029877-94-8 98%
    Trelagliptin (succinate) (Standard) is the analytical standard of Trelagliptin (succinate). This product is intended for research and analytical applications. Trelagliptin (SYR-472) succinate is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
    Trelagliptin succinate (Standard)
  • HY-15409S1
    Empagliflozin-13C6 98%
    Empagliflozin-13C6 (BI 10773-13C6) is 13C labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
    Empagliflozin-13C6
  • HY-15409S2
    Empagliflozin-d6 98%
    Empagliflozin-d6 (BI 10773-d6) is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
    Empagliflozin-d6
  • HY-15656AR
    Ceritinib dihydrochloride (Standard) 1380575-43-8 98%
    Ceritinib (LDK378) dihydrochloride (Standard) is the analytical standard of Ceritinib dihydrochloride (HY-15656A). This product is intended for research and analytical applications. Ceritinib dihydrochloride is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency.
    Ceritinib dihydrochloride (Standard)
  • HY-156648A
    Vamagloxistat sodium 2667602-26-6 98%
    Vamagloxistat (sodium) is glycolate oxidase inhibitor, used to inhibit hyperoxaluria and kidney stones.
    Vamagloxistat sodium
  • HY-157438A
    pppApA sodium 98%
    pppApA sodium is a linear dinucleotide intermediate in the enzymatic production of the bacterial signalling nucleotide c-diAMP. pppApA sodium is formed by conjugation between two molecules of ATP.
    pppApA sodium
  • HY-158825A
    Cepadacursen sodium scrambled negative control 98%
    Cepadacursen sodium scrambled negative control is the sequence scrambled negative control of Cepadacursen sodium.
    Cepadacursen sodium scrambled negative control
  • HY-158825B
    FAM labled Cepadacursen sodium 98%
    FAM labled Cepadacursen sodiumis a FAM labled Cepadacursen sodium.
    FAM labled Cepadacursen sodium
  • HY-158825C
    Cy3 labled Cepadacursen sodium 98%
    Cy3 labled Cepadacursen sodium is a Cy3 labled Cepadacursen sodium.
    Cy3 labled Cepadacursen sodium
  • HY-158827B
    AZD8233 sodium scrambled negative control 98%
    AZD8233 sodium scrambled negative control is the sequence scrambled negative control of AZD8233 sodium.
    AZD8233 sodium scrambled negative control
  • HY-158827C
    FAM labled AZD8233 sodium 98%
    FAM labled AZD8233 sodiumis a FAM labled AZD8233 sodium.
    FAM labled AZD8233 sodium
  • HY-158827D
    Cy3 labled AZD8233 sodium 98%
    Cy3 labled AZD8233 sodium is a Cy3 labled AZD8233 sodium.
    Cy3 labled AZD8233 sodium
  • HY-16397AR
    Phenformin hydrochloride (Standard) 834-28-6 98%
    Phenformin (Phenethylbiguanide) hydrochloride (Standard) is the analytical standard of Phenformin hydrochloride (HY-16397). This product is intended for research and analytical applications. Phenformin hydrochloride (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential.
    Phenformin hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity